Leptin inhibitor as a novel therapeutic for osteoarthritis

Osteoarthritis (OA) is a progressive disorder characterized by articular cartilage attrition and metabolic changes in the subchondral bone and the synovium. Recently, leptin was shown to be elevated in synovial fluid of patients with OA. Here, we propose to use leptin inhibitor as intraarticular injections to slow/prevent OA progression.