Ryanodine receptor leak triggers fiber Ca 2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle

Cedric R. Lamboley,Luke Pearce,Crystal Seng,Aldo Meizoso-Huesca,Daniel P. Singh,Barnaby P. Frankish,Vikas Kaura,Harriet P. Lo,Charles Ferguson,Paul D. Allen,Philip M. Hopkins,Robert G. Parton,Robyn M. Murphy,Chris van der Poel,Christopher John Barclay,Bradley S. Launikonis

Ryanodine receptor leak triggers fiber Ca 2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle

2021

Cedric R. Lamboley
Luke Pearce
Crystal Seng
Aldo Meizoso-Huesca
Daniel P. Singh
Barnaby P. Frankish
Vikas Kaura
Harriet P. Lo
Charles Ferguson
Paul D. Allen
Philip M. Hopkins
Robert G. Parton
Robyn M. Murphy
Chris van der Poel
Christopher John Barclay
Bradley S. Launikonis

Muscle contraction depends on tightly regulated Ca2+ release. Aberrant Ca2+ leak through ryanodine receptor 1 (RyR1) on the sarcoplasmic reticulum (SR) membrane can lead to heatstroke and malignant...

Keywords:

Chemistry
Muscle contraction
Heatstroke
Leak
RYR1
Endoplasmic reticulum
Basal metabolic rate
Cell biology
Skeletal muscle
Ryanodine receptor

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