Potentiating action of hexoprenaline on14C-aminopyrine uptake by isolated rat parietal cells

Hexoprenaline potentiated the14C-aminopyrine uptake (a reliable index of H+ generation) of isolated rat gastric cells stimulated by 10−6–10−4 mol/l carbachol, and inhibited that in response to 10−4 mol/l histamine without and in the presence of propranolol. It is concluded that hexoprenaline acts as a partial agonist on parietal cell H2-receptors and that β-adrenoceptor activation may functionally modualte gastric acid secretion.