Two Coordination Polymers Containing 4,4′-Di(1H-Benzo[D]Imidazol-1-yl)Biphenyl Ligand: Crystal Structures and Anticancer Activity on Human Multiple Myeloma Cells
2020
Solvothermal reactions of Co(NO3)2·6H2O or Ni(NO3)2·3H2O with 4,4′-di(1H-benzo[d]imidazol-1-yl)biphenyl (bimbb) and 2,6-pyridinedicarboxylic acid (H2pdc) afford two one-dimensional coordination polymers with the chemical formulas [Co(bimbb)2(pdc)](H2O)2(1) and [Ni(bimbb)2(pdc)](H2O)2(2). Complexes 1 and 2 are characterized by the elemental analysis and single crystal X-ray diffraction. The RPMI-8226 human multiple myeloma cell proliferation is determined by the CCK-8 assay after treatment with complexes 1 and 2. The morphological changes of treated RPMI-8226 are observed with the Hoechst staining method, and the apoptotic related protein levels are determined by western blot after treatment with complexes 1 and 2.
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