Pharmacodynamic activity and antithrombotic efficacy of RPR120844, a novel inhibitor of coagulation factor Xa.

Robert J. Leadley,Suzanne Morgan,Ross Bentley,Jeffrey S. Bostwick,Charles Kasiewski,Christopher L. Heran,Valeria Chu,Karen A. Brown,Phillip Moxey,William R. Ewing,Henry Pauls,Alfred P. Spada,Mark H. Perrone,Christopher T. Dunwiddie

Pharmacodynamic activity and antithrombotic efficacy of RPR120844, a novel inhibitor of coagulation factor Xa.

1999

Robert J. Leadley
Suzanne Morgan
Ross Bentley
Jeffrey S. Bostwick
Charles Kasiewski
Christopher L. Heran
Valeria Chu
Karen A. Brown
Phillip Moxey
William R. Ewing
Henry Pauls
Alfred P. Spada
Mark H. Perrone
Christopher T. Dunwiddie

Summary:These studies were designed to examine the pharmacodynamic profile and antithrombotic efficacy of RPR120844, a competitive inhibitor of coagulation factor Xa, with a Ki of 7 nM against human factor Xa. In vitro, RPR120844 doubled activated partial thromboplastin time (APTT) at concentrations

Keywords:

Prothrombin time
Cardiology
In vivo
Pharmacodynamics
Antithrombotic
Biological activity
Partial thromboplastin time
In vitro
Endocrinology
Internal medicine
Pharmacology
Pharmacokinetics
Chemistry

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