Interleukin-1β enhances cell migration through AP-1 and NF-κB pathway-dependent FGF2 expression in human corneal endothelial cells

Background Information Interleukin 1β is a major pro-inflammatory cytokine that plays a crucial role in the regulation of inflammation and wound healing in the cornea. Elucidation of Interleukin1β signaling may help identify therapeutic targets for corneal wound healing; however, mechanisms such as cell migration, a component of Interleukin 1β induced wound healing response in human corneal endothelial cells, have not been well characterized.