Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation

The expression of the nucleolar protein nucleophosmin (NPM) decreases during the differentiation of various cell types. Here, the authors show that the collaboration between the RNA-binding proteins, HuR and KSRP, reduces the stability of NPM mRNA in myoblasts, thereby allowing myogenesis.