Single Gene Generalized Epilepsy in Africa

The study of families with epilepsy has unraveled several mysteries about the pathophysiology of the disease. However, the majority of those studies were conducted on non-African populations. Africa is strongly believed to be the origin of humans and thus the African genome must give a more comprehensive view of Mendelian diseases. In this review, we have navigated the genes predisposing to familial genetic epilepsies in Africa and compared those to the genes identified worldwide looking for a unique African flavor in familial epilepsies.