Cardiovascular Disease in Hospitalizations With a Diagnosis of Coronavirus From Pre-COVID-19 Era in United States: National Analysis From 2016-2017

Objective To analyze the cardiovascular disease (CVD) burden in hospitalized patients with a diagnosis of coronavirus from pre-COVID-19 era in United States (US) Patients and Methods We identified adult hospitalizations with a diagnosis of coronavirus in a large US administrative database, National (Nationwide) Inpatient Sample (January 1, 2016 to December 3, 2017) to study patient demographics, clinical comorbidities and outcomes (in-hospital mortality and healthcare resource utilization) based upon presence or absence of CVD Results A total of 21,300 adult hospitalizations with a diagnosis of coronavirus from 2016 to 2017 all across US were included in the final analysis;the mean age was 63 6 years, 51 8% were female and 74 7% public insurers Among these, 11,930 hospitalizations (56 0%) had a diagnosis of CVD Compared with those without CVD, hospitalizations with CVD were older (age, 70 1 vs 55 4 years), had higher Charlson comorbidity score (2 5 vs 1 6) and Elixhauser comorbidity index (4 3 vs 2 4) (all p< 001) After multivariable risk adjustment, hospitalizations with CVD had higher mortality than those without CVD (5 3% vs 1 5%;adjusted odds ratio = 2 0, 95% CI 1 2 to 3 4, p= 008) The mean length of stay (6 9 vs 6 1 days, p= 003), hospital charges (78,377 vs 66,538 US dollars, p= 002) and discharge disposition to nursing home was higher in those with CVD (24 6% vs 12 9%, p< 001) when compared to no-CVD group Conclusion: CVD was present in a significant proportion of hospitalizations with coronavirus in pre-COVID-19 era in US and was associated with higher risk of in-hospital mortality and healthcare resource utilization