Impact of Age on Gender Difference in Long-term Outcome of Patients with Acute Myocardial Infarction (From J-MINUET).

Although gender difference in long-term outcomes after acute myocardial infarction (MI) have been shown previously, impact of age on gender difference is still controversial. This study focused on the association between age and gender difference in long-term outcome. We analyzed data from 3283 consecutive patients who were included in a prospective, nationwide, multicenter registry (J-MINUET) from 2012 to 2014. The primary endpoint was the major adverse cardiovascular event (MACE), which was defined as a composite of death, MI, stroke, heart failure, and revascularization for unstable angina during 3 years. Patients were divided into 4 strata according to age: those with age <65 years (group 1: n=1161), 65-74 years (group 2: n=954), 75-84 years (group 3: n=866) and 84< years (group 4: n=302). Although the crude incidence of 3-year MACE was significantly higher in women than men (36.4% vs. 28.5%, P<0.001), there was not significant gender difference in each group (group 1, 19.6% vs. 19.0%, P=0.74; group 2, 33.1% vs. 28.3%, P=0.25; group 3, 38.9% vs. 39.6%, P=0.54; and group 4, 54.0% vs. 56.8%, P=0.24). In conclusion, although women had higher crude incidence of 3-year MACE than men, there was no gender difference in each group.