Development and Validation of Analytical Methodology for the Determination of Volatile Organic Compounds for Production and Certification of Reference Material

An analytical method has been developed and validated for the determination of benzene, toluene, ethylbenzene and xylenes (BTEX) using gas chromatography - ion trap mass spectrometry (GC - IT - MS - ID) with isotope dilution. The limits of detection (LOD) and limits of quantification (LOQ) were always lower than 5 and 15 ug/g, respectively. The linear correlation coefficients were always greater than 0.99. The certified reference material was used for determination of the accuracy and precision of the method. The obtained results were satisfactory and agreed with the evaluated performance parameters.