The effect of nateglinide on the pharmacokinetics and

Results: The mean (coefficient of variation (CV%)) area under the concentration‐time curve (AUC 0‐t ) of R-acenocoumarol in the presence and absence of nateglinide was 4217 (23%) and 3831 (24%) ng.h/ml, respectively. The corresponding values for S-acenocoumarol were 397 (20%) and 382 (23%), respectively. The mean (CV%) C max of R-acenocoumarol in the presence and absence of nateglinide was 304 (16%) and 316 (16%), respectively and the corresponding values for Sacenocoumarol were 142 (36%) and 141 (34%),