Synthesis and antibacterial properties of 4-bromobenzohydrazide derivatives and crystal structure of (E)-N′-((1H-indol-3-yl)methylene)-4-bromobenzohydrazide

Six 4-bromobenzohydrazide derivatives (1–6) were synthesized by the condensation reaction of 4-bromobenzohydrazide and benzaldehydes, and evaluated for antibacterial activity. Their structures were determined by spectroscopic methods. In addition, the crystal structure of compound 6 was characterized by single crystal X-ray structure determination. In crystal packing, the molecules are linked by N–H···O and N–H···N hydrogen bonds into two-dimensional network parallel to the (001) plane. The crystal is further stabilized by weak C–H···O and C–H···π interactions.