Radical‐Promoted Distal C‐H Functionalization of C(sp3) Centers with Fluorinated Moieties

Due to their unique properties, fluorinated scaffolds are pivotal compounds in pharmaceuticals, agrochemicals and materials science. Over the last years, the development of versatile strategies for the selective synthesis of fluorinated molecules by direct C-H bond functionalization has attracted a lot of attention. In particular, the design of novel transformations based on a radical process was a bottleneck for the distal C-H functionalization reactions, offering synthetic solutions for the selective introduction of a fluorinated group. This Minireview highlights the major contributions that have been made in this blossoming field. The development of new methodologies for the remote functionalization of aliphatic derivatives with various fluorinated groups based on a 1,5-HAT process and a b-fragmentation reaction will be mainly showcased and discussed.