Direct Synthesis of 2-Substituted Benzonitriles via Alkylcyanation of Arynes with N,N-Disubstituted Aminomalononitriles

Wen Bao,Zhu-Peng Gao,Da-Ping Jin,Cao-Gen Xue,Huan Liang,Lin-Sheng Lei,Xuetao Xu,Kun Zhang,Shao Hua Wang

Direct Synthesis of 2-Substituted Benzonitriles via Alkylcyanation of Arynes with N,N-Disubstituted Aminomalononitriles

2020

Wen Bao
Zhu-Peng Gao
Da-Ping Jin
Cao-Gen Xue
Huan Liang
Lin-Sheng Lei
Xuetao Xu
Kun Zhang
Shao Hua Wang

An efficient alkylcyanation of in situ generated arynes by N,N-disubstituted aminomalononitriles is described, enabling the direct synthesis of 2-substituted benzonitriles.

Keywords:

In situ
Organic chemistry
Aryne
Chemistry

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