Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway

Kayo Kondo,Hila Shaim,Philip A Thompson,Jan Andreas Burger,M. Keating,Zeev Estrov,David Harris,Ekaterina Kim,Alessandra Ferrajoli,May Daher,Rafet Basar,Muharrem Muftuoglu,Nobuhiko Imahashi,Abdullah Alsuliman,Catherine Sobieski,Elif Gokdemir,William G. Wierda,Nitin Jain,Enli Liu,Elizabeth J. Shpall,Katy Rezvani

Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway

2018

Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway

Keywords:

Cancer research
Regulatory B cells
STAT3
PD-L1
Pharmacology
Biology
Ibrutinib
STAT protein
Chronic lymphocytic leukemia
Bruton's tyrosine kinase
Immune tolerance
Tumor microenvironment

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