IDENTIFICATION AND CHARACTERISATION OF THE ISOMERS OF CYCLOTHIAZIDE RESPONSIBLE FOR POTENTIATING AMPA CURRENT
1994
Abstract The four diastereoisomers of cyclothiazide have been separated by chromatography. The most potent fraction was split further into two enantiomers by chiral HPLC. The most active isomer is five times more potent than cyclothiazide in potentiating AMPA transmission in rat cortex mRNA injected Xenopus oocytes.
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