SYNTHESIS OF SOME 6-((ALKYLAMINO) METHYL HEXAHYDRO-5 5-A ARYL-A AND ARALKYL-4 4, 7-M METHANOINDAN-5 5-O OLS AND CERTAIN OF THEIR PROPIONATE ESTERS AS ANALGESICS

SUMMARY : The synthesis and screening of the analgesic activity of a series of 6-(alkylamino) methyl hexahydro-5-aryl-and aralkyl-4,7-methanoindan-5-ols (2 a-p) and the corresponding propionate esters 6b, c, g, k and m are described. Some of these tertiary alcohols exhibited slight analgesic potency comparable with that of Tramadol i the hot-plate test.