Ultrasound-assisted tandem synthesis of tri- and tetra-substituted pyrrole-2-carbonitriles form alkenes, TMSCN and N,N-disubstituted formamides

Abstract An energy-saving and eco-friendly method for the efficient construction of various tri- and tetra-substituted pyrrolecarbonitriles through ultrasound-assisted multicomponent tandem reaction of readily available alkenes, TMSCN and N,N-disubstituted formamides within 40 min under metal-, solvent-free and mild conditions was developed. The dual role of iodine (catalyst and oxidant) notably simplified the reaction conditions and reduced the chemical waste generated