Haloacetylated enol ethers: 4 [6]. Synthesis of 4‐trihalomethyl‐2‐methylthiopyrimidines

The synthesis of a series of 5- and 6-substituted 4-trihalomethyl-2-methylthiopyrimidines, prepared from the cyclocondensation reaction of β-alkoxyvinyl tri[fluoro]chloromethyl ketones with 2-methyl-2-thiopseudourea sulfate, are reported. A systematic study to find the best reaction conditions were carried out.