Promoter-driven splicing regulation in fission yeast

Rem1 expression is controlled not only at the level of transcription, but also by splicing. In mitotic cells, binding of the Fkh2 transcription factor to the rem1 promoter yields a transcript that retains its introns so that only a short protein is produced; this protein affects recombination levels. In meiotic cells, the binding of the meiosis-specific trancription factor Mei4 to the rem1 promoter results in splicing of rem1, yielding the cyclin isoform. Thus, this work demonstrates that two transcription factors can differentially affecting splicing of the same gene.