Real-time precise microfluidic droplets label-sequencing combined in a velocity detection sensor.
2021
Droplets microfluidics is broadening the range of Lab on a Chip
solutions that, however, still suffer from the lack of an adequate level
of integration of optical detection and sensors. In fact, droplets are
currently monitored by imaging techniques, mostly limited by a
time-consuming data post-processing and big data storage. This work aims
to overcome this weakness, presenting a fully integrated
opto-microfluidic platform able to detect, label and characterize
droplets without the need for imaging techniques. It consists of optical
waveguides arranged in a Mach Zehnder’s configuration and a
microfluidic circuit both coupled in the same substrate. As a proof of
concept, the work demonstrates the performances of this
opto-microfluidic platform in performing a complete and simultaneous
sequence labelling and identification of each single droplet, in terms
of its optical properties, as well as velocity and lengths. Since the
sensor is realized in lithium niobate crystals, which is also highly
resistant to chemical attack and biocompatible, the future addition of
multifunctional stages into the same substrate can be easily envisioned,
extending the range of applicability of the final device.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
52
References
0
Citations
NaN
KQI