Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica.

Abstract Six new phenolics, scutellariosides A–F ( 1 – 3 , 5 – 6 , and 8 ), together with six known compounds ( 4 , 7 , 9 – 12 ) were isolated from the whole plant of Scutellaria indica (Labiatae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR. Their anti-inflammatory activities were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells. Among them, compounds 10 – 12 had inhibitory effects with IC 50 values ranging from 7.2 to 27.8 μM. Compound 12 reduced LPS-induced iNOS expression in a dose-dependent manner.