A method of sequencing of biopolymers

2013 
The invention relates to a method and a corresponding arrangement for sequencing of at least two biopolymers (6), wherein to each biopolymer (6), a sequence signal is received by a respective measurement sensor, depending on the sequence of the biopolymer (6), the sequence of signals (in a shift register are transmitted 16) and stored there, the buffered sequence signals from the shift register (16) are sequentially transferred to an evaluation device (26) and evaluated there. Each sequence signal is generated preferably by means of a nanopore array (10). In a corresponding Sequenzieranordnung (11) the measurement sensor and the shift register (16) are preferably in an electrical circuit, so on a sensor array, for example, integrated. Each sequence signal can prior to transfer into the shift register (16) of a preamplifier (14) to be strengthened. Transmitting the output signal (A) to the evaluation device (24) may include amplifying the signal by an output amplifier (24) and / or at least one EMCCD stage (32).
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