Anodal tDCS of right temporo-parietal junction promotes threat detection in low-spatial-frequency channels.

Abstract Fast detection of threat is crucial for survival. Previous studies have suggested the involvement of low- and high-spatial-frequency (LSF and HSF) information in the process of threat detection. However, the specific contributions of LSF and HSF information to it are still controversial. Here we probed this issue by utilizing a prime procedure coupled with the transcranial direct current stimulation (tDCS) technique. Specifically, in a single-blind design, participants were exposed to LSF or HSF faces prior to the presentation of looming or receding spheres. Meanwhile, tDCS was applied over the right or left temporo-parietal junction (TPJ), which has been found to be preferentially associated with the processing of LSF and HSF information, respectively. The results showed significant LSF-related facilitation of threat detection when anodal tDCS was applied to the right TPJ. However, HSF-related facilitation of threat detection was not observed when anodal tDCS was applied to the left TPJ. The findings support the idea that LSF information can facilitate threat detection, and provide direct evidence that the right TPJ is vital for LSF-related facilitation of threat detection.