Acrosin structure-based design, synthesis and biological activities of 7-azaindol derivatives as new acrosin inhibitors

2011 
Abstract A series of 7-azaindol derivatives were designed based on the homologous 3D model of human acrosin. These compounds were synthesized and evaluated for their human acrosin inhibitory activities in vitro . Compounds 7a , 7i , 7j , 7k and 7n showed highly inhibitory activity against human acrosin. The three-dimensional structure–activity relationship was investigated through a CoMFA model, which provided valuable information to further study of potential human acrosin inhibitors.
    • Correction
    • Source
    • Cite
    • Save
    • Machine Reading By IdeaReader
    6
    References
    8
    Citations
    NaN
    KQI
    []