IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.

Abstract Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2- a ]pyridino-pyridines and benzimidazolo-pyridines was explored.