Pyrazole-O-glucosides as Novel Na+-Glucose Cotransporter (SGLT) Inhibitors.

Koji Ohsumi,Hiroyuki Matsueda,Toshihiro Hatanaka,Ryusuke Hirama,Takashi Umemura,Akiko Oonuki,Nozomu Ishida,Yoko Kageyama,Katsumi Maezono,Nobuo Kondo

Pyrazole-O-glucosides as Novel Na+-Glucose Cotransporter (SGLT) Inhibitors.

2003

Koji Ohsumi
Hiroyuki Matsueda
Toshihiro Hatanaka
Ryusuke Hirama
Takashi Umemura
Akiko Oonuki
Nozomu Ishida
Yoko Kageyama
Katsumi Maezono
Nobuo Kondo

O-glucuronides and O-glucosides of a series of pyrazoles analogues were synthesized and evaluated for their SGLT inhibitory activity in brush border membrane vehicles (BBMVs) of rat kidney. O-glucosides of certain pyrazole analogues inhibited the transport of [(14)C]-glucose in BBMVs, and induced glucosuria in Wistar rats by intravenous injection.

Keywords:

Cotransporter
Pyrazole
Combinatorial chemistry
SGLT Inhibitors
Chemistry
Organic chemistry
Biochemistry
na glucose cotransporter

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