HNF4-α ANTAGONIST AND USE THEREOF

The invention HNF4-α (Hepatocyte nuclear factor 4 alpha) antagonists and relates to their use relates to HNF4-α (Hepatocyte nuclear factor 4 alpha) antagonist and its use of the present invention, HNF4-α screened by the present invention antagonists was confirmed that for the specific binding to the ligand binding domain of HNF4-α inhibitory activity of HNF4-α, HNF4-α antagonist of the invention is significantly Wnt5a expression compared to HNF4-α antagonist, the known to reduce the specific, for the treatment or prevention of the above diseases can suppress the growth of cancer cells, not only it can be used as a pharmaceutical composition or dietary supplement for cancer prevention and treatment, caused by HNF4-α over-expression It can be applied to the composition.