Interaction of large granular lymphocytes with susceptible target does not induce second messenger And cytolytic granule exocytosis

We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca 2+ ] i rise and cytolytic granule exocytosis, and most likely involves alternative, as get unidentified, mechanisms