Enzyme technologies : metagenomics, evolution, biocatalysis, and biosynthesis

Contributors. Preface. PART A NEW APPROACHES TO FINDING AND MODIFYING ENZYMES. 1 Functional Metagenomics as a Technique for the Discovery of Novel Enzymes and Natural Products (Luke A. Moe, Matthew D. McMahon, and Michael G. Thomas). 2 Directed Enzyme and Pathway Evolution (Jacob Vick and Claudia Schmidt-Dannert). 3 Combining Natural Biodiversity and Molecular-Directed Evolution to Develop New Industrial Biocatalysts and Drugs (Laurent Fourage, Celine Ayrinhac, Johann Brot, Christophe Ullmann, Denis Wahler, and Jean-Marie Sonet). 4 Principles of Enzyme Optimization for the Rapid Creation of Industrial Biocatalysts (Richard J. Fox and Lori Giver). PART B BIOCATALYTIC APPLICATIONS. 5 Enzyme Catalysis in the Synthesis of Active Pharmaceutical Ingredients (Animesh Goswami). 6 Enzymatic Processes for the Production of Pharmaceutical Intermediates (David Rozzell and Jim Lalonde). 7 Novel Developments Employing Redox Enzymes: Old Enzymes in New Clothes (Kurt Faber, Silvia M. Glueck, Birgit Seisser, and Wolfgang Kroutil). PART C BIOSYNTHETIC APPLICATIONS. 8 Drug Discovery and Development by Combinatorial Biosynthesis (Matthew A. DeSieno, Carl A. Denard, and Huimin Zhao). 9 Reprogramming Daptomycin and A54145 Biosynthesis to Produce Novel Lipopeptide Antibiotics (Richard H. Baltz, Kien T. Nguyen, and Dylan C. Alexander). 10 Pathway and Enzyme Engineering and Applications for Glycodiversification (Lishan Zhao and Hung-wen Liu). Index.