HLA-G expression of cervical reserve cell-like cells regenerated from human induced pluripotent stem (iPS) cells and its relationship with cervical cancer stem cells in immune escape

s / Journal of Reproductive Immunology 112 (2015) 121–140 125 pregnant mice. During pregnancy in mice, continuous infusion of high-dose angiotensin II (AngII) induced hypertension, proteinuria, and IUGR, whereas infusion of low-dose AngII caused hypertension alone. AngII-induced hypertension was prevented in Nlrp3−/− mice but not in Asc−/−, indicating that NLRP3 contributes to gestational hypertension independently of ASC-mediated inflammasomes. Although NLRP3 deficiency had no effect on IUGR, it restored IL-6 upregulation in the placenta and kidney of AngIIinfused mice. These findings demonstrate that NLRP3 contributes to the development of gestational hypertension independently of the inflammasomes. http://dx.doi.org/10.1016/j.jri.2015.09.016