Optimizing the delivery of deep brain stimulation using electrophysiological atlases and an inverse modeling approach
2012
The use of deep brain stimulation (DBS) for the treatment of neurological movement degenerative disorders requires the
precise placement of the stimulating electrode and the determination of optimal stimulation parameters that maximize
symptom relief (e.g. tremor, rigidity, movement difficulties, etc.) while minimizing undesired physiological side-effects.
This study demonstrates the feasibility of determining the ideal electrode placement and stimulation current amplitude
by performing a patient-specific multivariate optimization using electrophysiological atlases and a bioelectric finite
element model of the brain. Using one clinical case as a preliminary test, the optimization routine is able to find the most
efficacious electrode location while avoiding the high side-effect regions. Future work involves optimization validation
clinically and improvement to the accuracy of the model.
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