Forecasting Transmission Dynamics of COVID-19 in India Under Containment Measures- A Time-Dependent State-Space SIR Approach

The primary objective of this paper is to predict the dynamics of COVID-19 epidemic in India while adjusting for the effects of various progressively implemented containment measures Apart from forecasting the major turning points and parameters associated with the epidemic, we intend to provide an epidemiological assessment of the impact of these containment measures in India This paper proposes a method based on time-series SIR (Susceptible, Infected, and Removed) model to estimate time-dependent modifiers for transmission rate of the infection These modifiers are used in state-space SIR model to estimate the basic reproduction number R-0 and expected total incidence, and to forecast the daily prevalence till the end of the epidemic We consider four different scenarios, two based on current developments and two based on hypothetical situations for the purpose of comparison Assuming gradual relaxation in lockdown post 17 May 2020, we expect the prevalence of infecteds to cross 9 million, with at least 1 million severe cases, around the end of October 2020 For the same case, estimates of R-0 for the phases no-intervention, partial-lockdown and lockdown are 4 46 (7 1), 1 47 (2 33), and 0 817 (1 29) respectively, assuming 14-day (24-day) infectious period Estimated modifiers give consistent estimates of unadjusted R-0 across different scenarios, demonstrating precision Results corroborate the effectiveness of lockdown measures in substantially reducing R-0 Also, predictions are highly sensitive towards estimate of infectious period