Design and Synthesis of Biotinylated Troglitazone as an Active Affinity Probe
2010
A biotin-tagged analogue of troglitazone was designed, synthesized and applied to affinity chromatography to pulldown EGFR from 293T cell lysates overexpressing EGFR, a membrane protein assumed to be troglitazone's direct binding target by previous work. The results indicate the feasibility of the biotinylated probe as a vigorous tool to clarify the molecular mechanisms for troglitazone's antitumor activities.
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