Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System

Chikako Imada,Takuma Takahashi,Makoto Kuramoto,Kazufumi Masuda,Ken Ichi Ogawara,Akira Sato,Yusuke Wataya,Hye-Sook Kim,Kazutaka Higaki

Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System

2015

Chikako Imada
Takuma Takahashi
Makoto Kuramoto
Kazufumi Masuda
Ken Ichi Ogawara
Akira Sato
Yusuke Wataya
Hye-Sook Kim
Kazutaka Higaki

Purpose The objective of this study was to improve the absorption behavior of N-251, a novel antimalarial drug, by preparing an appropriate self-nanoemulsifying drug delivery system (SNEDDS).

Keywords:

Drug
Absorption (pharmacology)
Drug delivery
Medium chain fatty acid
Lymphatic system
Bioavailability
Pharmacology
Chemistry
Biochemistry
Long chain fatty acid
pharmacology toxicology
self nanoemulsifying

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