solid pharmaceutical composition dispersible and / or orodispersible non-laminated contains at least the active ingredient metformin and method of preparing
2003
The invention relates to a dispersible pharmaceutical composition and solid orodispersible immediate release is in the form of particles having a size less than 710 m, containing the active ingredient metformin, characterized in that it comprises: a) 65% to 90% by weight of the active ingredient metformin, optionally in the form of a salt, or a combination of the metformin active ingredient with an active ingredient hypoglycemiant.b) from 0.5 to 4% by weight of a binding agent or combination of binding agents, c) from 1% to 12% by weight of a disintegrant or combination of disintegrants, d) from 0% to 10% by weight of a diluent or combination of diluents, e) from 0.05% to 3% by weight of a sweetening agent or a combination of sweetening agents; and f) one or more additional excipients, the percentages by weight being expressed relative to the total weight of said composition.
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