Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough.

Robbie L. McLeod,Deen Tulshian,Ginny D. Ho,Xiomara Fernandez,Donald C. Bolser,Leonard E. Parra,Jennifer C. Zimmer,Christine H. Erickson,Ahmad Fawzi,Huchappa Jayappa,Craig Lehr,Jason Erskine,April Smith-Torhan,Hongtao Zhang,John A. Hey

Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough.

2009

Robbie L. McLeod
Deen Tulshian
Ginny D. Ho
Xiomara Fernandez
Donald C. Bolser
Leonard E. Parra
Jennifer C. Zimmer
Christine H. Erickson
Ahmad Fawzi
Huchappa Jayappa
Craig Lehr
Jason Erskine
April Smith-Torhan
Hongtao Zhang
John A. Hey

Background: Previous studies have demonstrated that nociceptin/orphanin FQ (N/OFQ), the endogenous peptide ligand for the G-protein-coupled NOP receptor, inhibits cough in experimen

Keywords:

Endocrinology
Tracheobronchitis
Internal medicine
Agonist
Pharmacology
Ligand (biochemistry)
Nociceptin receptor
NOP
Opioid receptor
Guinea pig
Chemistry
Receptor
Endogeny
Sensory nerve

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