Candicanoside A, a Novel Cytotoxic Rearranged Cholestane Glycoside from Galtonia candicans

A novel cholestane diglycoside, named candicanoside A (1), was isolated from the bulbs of Galtonia candicans by monitoring the cytotoxic activity on HL-60 leukemia cells. Candicanoside A (1) is very unique in structure, having two epoxy functionalities in its rearranged cholestane skeleton, and showed differential cytotoxicity in the Japanese Foundation for Cancer Research 38 cell-line assay.