Cyperane and eudesmane-type sesquiterpenoids from Chinese liverwort and their anti-diabetic nephropathy potential

Six new sesquiterpenoids, including cyperane (1 and 2) and eudesmane (3–6) types, and one known eudesmane derivative (7), were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis (Schrad.) Nees. The structures of 1–7 were determined based on a combination of their spectroscopic data (NMR, HRESIMS and IR), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculations. Preliminary anti-diabetic nephropathy activity testing showed that the cyperane-type sesquiterpenoids could inhibit cell proliferation and extracellular matrix accumulation in high glucose cultured mesangial cells in a dose-dependent manner.