Manganese inhibits Nickel-stimulated Calcineurin Enzyme Activity by Uncompetitive Inhibition

Ca CaM !"# $%&' 2 B()*+,-*./0CN 123,4256/7! 89: ; ? : @A5B.*C D EFGH )*B# IJ TK 5BL/' %'M N2 O: PQ RS T UVK W DX5B.* C D EFYZ[\!"/0K ] CN^ Ca _ CaM "/. ` a bc5de*f 5ghi*./(jI,-/; CN in vitro ! k l Mn _ mn Ni dZDopCqr!^ s tu i-/v(; ,3(De*./ 5 07H wx y-y: z{| }~ Zn ; Ni(  €‚5d# CN^ F‚=/v(F ,3() i,5ƒ„ …ƒ„ † ‡ ƒ„ † ƒ„ ; Nitu)H CN^ Fo‰ 5‚=/ v(F Š)*‹H 8 0v dZ5 CN > D Œ\5B.*^ ŽFL/v(;

Keywords:

• Calcineurin
• Enzyme inducer
• Photochemistry
• Non-competitive inhibition
• Uncompetitive inhibitor
• Enzyme assay
• Manganese
• Chemistry
• Nickel
• Medicinal chemistry

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