Two new tetrahydroisoquinoline analogs from Indian medicinal plant Annona squamosa

Abstract Objective To investigate the bioactive principles obtained from chloroform extract of Indian medicinal plant Annona squamosa . Methods The successively extracted twigs of A. squamosa using various solvents were analyzed for their antiulcer activity and finally two new compounds are isolated and characterized based on bioassay guided fractionation and isolation. Results Isolated compounds (compound no. 1 & 2 ) were examined for Hydrogen Potassium ATPase activity. When compared to the standard drug omeprazole, both compounds are showing better activity. Conclusions The results obtained justify the traditional usage of A. squamosa for their antisecretory activity.