Luteal production of steroids and prostaglandins during simulated early pregnancy in the primate: differential regulation of steroid production by chorionic gonadotropin.

Stimulation of the primate corpus luzeum (CL) by endogenous chorionic gonadotropin (CG) in early pregnancy, or by exogenous human (h)CG in simulated early pregnancy, results in a transient elevation of serum progesterone (P) and a persistent elevation of serum I 7�-estradiol (E). Luteal prostaglandins (PG) may play a role in these responses. The objective of the current study was to correlate Iweal PG production and steroidogenic response of CL in vitro with patterns of serum steroids during simulated early pregnancy. CL were removed from rhesus monkeys (n = 26) at Oh, 9 h, 3 days, 6 days, and 10 days, during prolonged CG exposure of simulated early pregnancy. Dispersed cells were incubated in vitro at 37 Vfor 8 h. Changes in basal production of P were not significantly correlated with patterns of serum steroids. Maximal stim_ulation of P production by hCG in vitro (stimulated minus basal) continuously declined (p

Keywords:

• Anatomy
• Luteal phase
• Internal medicine
• Basal (phylogenetics)
• Endocrinology
• Biology
• Corpus luteum
• Gonadotropin
• Stimulation
• Gestation
• Radioimmunoassay
• Pregnancy

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