Lipid-Based Tumor-targeted Systems

With the booming development of bionanotechnology, a variety of multifunctional nanoparticle platforms have been explored to facilitate drug delivery in cancer treatment. Thanks to their good biocompatibility and versatile structures, the lipid-based nanoparticles can serve as ideal candidates to carry therapeutic reagents to cancer tissues. Additionally, the natural polymeric coating of liposomes could easily fuse with cellular membrane and minimize clearance by blood circulation. To date, their composition, properties, targeting strategies, reasonable design methods, and pharmacokinetics have been extensively studied to facilitate preclinical and clinical translations. In this chapter, we will introduce the structure and function of the lipid-based nanoparticle system, and a comprehensive review of the lipid-based nanoparticle drug delivery system will be presented.