Producing fucoxanthin from algae - Recent advances in cultivation strategies and downstream processing.

Fucoxanthin, a brown-colored pigment from algae, is gaining much attention from industries and researchers recently due to its numerous potential health benefits, including anti-oxidant, anti-cancer, anti-obesity functions, and so on. Although current commercial production is mainly from brown macroalgae, microalgae with rapid growth rate and much higher fucoxanthin content demonstrated higher potential as the fucoxanthin producer. Factors such as concentration of nitrogen, iron, silicate as well as light intensity and wavelength play a significant role in fucoxanthin biosynthesis from microalgae. Two-stage cultivation approaches have been proposed to maximize the production of fucoxanthin and other valuable metabolites. Sustainable fucoxanthin production can be achieved by using low-cost substrates as a culture medium in an open pond cultivation system utilizing seawater with nutrient recycling. For downstream processing, the integration of novel "green" solvents with other extraction techniques emerged as a promising extraction technique.