Past, present, and future perspectives on the assessment of bioavailability/bioaccessibility of polycyclic aromatic hydrocarbons: A 20-year systemic review based on scientific econometrics

Bioaccessibility/bioavailability (bioac-bioav) is an important criterion in the risk assessment of polycyclic aromatic hydrocarbons (PAHs), especially in the restoration of contaminated sites. Although, the bioac-bioav concept is widely employed in PAH risk assessment for both humans and wildlife, their growth and integration in risk assessment models are seldom discussed. Consequently, the relevant literature listed on Web of Science (WOS)™ was retrieved and analyzed using the bibliometric software Citespace in order to gain a comprehensive understanding of this issue. Due to the limitations of the literature search software, we manually searched the articles about PAHs bioac-bioav that were published before 2000. This stage focuses on research on the distribution coefficient of PAHs between different environmental phases and laid the foundation for the adsorption-desorption of PAHs in subsequent studies of the bioac-bioav of PAHs. The research progress on PAH bioac-bioav from 2000 to the present was evaluated using the Citespace software based on country- and discipline-wise publication volumes and research hotspots. The development stages of PAH bioac-bioav after 2000 were divided into four time segments. The first three segments (2000-2005, 2006-2010, and 2011-2015) focused on the degradation of PAHs and their in vivo (bioavailability)-in vitro (bioaccessibility) evaluation method and risk assessment. Meanwhile, the current (2016-present) research focuses on the establishment of analytical methods for assessing PAH derivatives at environmental concentrations and the optimization of various in vitro digestion methods, including chemical optimization (sorptive sink) and biological optimization (Caco-2 cell). The contents are aimed at supplying researchers with a deeper understanding of the development of PAH bioac-bioav.