A New Peroxy-multiflorane Triterpene Ester from the Processed Seeds of Trichosanthes kirilowii

A new peroxy-multiflorane triterpene ester, (3α,5α,8α,20α)-5,8-epidioxymultiflora-6,9(11)-diene-3,29-diol 3,29-dibenzoate (1), was isolated from the processed seeds of Trichosanthes kirilowii, together with the two known related derivatives 2 and 3, and the two known steroids 4 and 5. Compounds 2, 4, and 5 were isolated from the genus Trichosanthes for the first time. The structure of compound 1 was established by NMR, HR-MS, and CD analyses. Compounds 1–3 were tested for their in vitro cytotoxicity against human-tumor cell lines (Hela, HL-60, and MCF-7) and anti-inflammatory activity (LPS-induced B lymphocyte cells) with the MTT method.