Synthesis of 3-Aminopyrrolidin-2-ones by an Intramolecular Reaction of Aziridinecarboxamides.

Abstract The synthesis of 4,5-disubstituted-3-amino-γ-lactams from N-substituted aziridinecarboxamides is described. Bicyclic aziridine derivatives were obtained from 1-N-Boc-aziridinecarboxamides under kinetically controlled conditions. Oxiranecarboxamides showed similiar behavior and gave 3-hydroxylactams.