Two new phenolic glycosides from the barks of Hydnocarpus annamensis and their anti-inflammatory and anti-oxidation activities

Two new phenolic glycosides 1 and 2 were isolated from the barks of Hydnocarpus annamensis, along with eighteen known compounds. The structures of all compounds were deduced using spectroscopic methods. Anti-inflammatory and anti-oxidation activities were evaluated. Among the isolates, compounds 1, 5,15 and 17 exhibited COX-2 inhibitory activities, with an inhibitory rate of 60.3 - 63.4% at 10μM. Compounds 7,12,13 and 20 showed anti-oxidation capacities in the DPPH free-radical assay, with a scavenging effect of 60.9-69.4% at 50pM, and 18.5-34.6% at 10μM.