Copper-Catalyzed Carbonylative Synthesis of Pyrrolidine-Containing Amides from γ,δ-Unsaturated Aromatic Oxime Esters
2020
A new method of low-cost copper-catalyzed carbonylative cyclization for preparing pyrrolidine-containing amides from γ,δ-unsaturated aromatic oxime esters and amines has been described. A range of readily available amines were examined, including primary, secondary, and heterocycle amines, giving over 60 examples of targeted N-heterocycle substituted amides with broad functional group tolerance, good chemical selectivity and moderate to excellent yields.
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